Handicapped definition, Sometimes Offensive. physically or mentally disabled. See more. handicap meaning, definition, what is handicap: a condition in which part of your body or mind has been permanently damaged or does not. Learn more. Define handicapped: having a physical or mental disability also: of or reserved for disabled persons — handicapped in a sentence. Spell It Can you spell these 10 commonly misspelled words? Word Origin and History for handicapped Expand. He was handicapped in his flight by the weight of the girl whose legs would but scarce bear her weight, to say nothing of maintaining her in rapid flight, for the tightly drawn bonds that had been about her ankles for so long had stopped circulation and partially paralyzed her extremities. Saenz set an orange plastic sled at the top of a handicapped access ramp. Test your knowledge of words related to the season of longer days and vacations. Handicapped Adults of Volusia County Handicapped And Retarded Citizens, Inc.